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課程名稱 |
高等有機化學一
Advanced Organic Chemistry (Ⅰ) |
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開課學期 |
107-2 |
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授課對象 |
理學院 化學所化學組 |
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授課教師 |
王宗興 |
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課號 |
Chem7027 |
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課程識別碼 |
223 M1230 |
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班次 |
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學分 |
4.0 |
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全/半年 |
半年 |
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必/選修 |
必修 |
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上課時間 |
星期一3,4(10:20~12:10)星期五3,4(10:20~12:10) |
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上課地點 |
化210室化210室 |
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備註 |
本課程中文授課,使用英文教科書。化學組學生優先選修，化生組學生及大學生、外系所學生，請於開學後，獲授課老師同意加簽
限碩士班以上 且 限本系所學生(含輔系、雙修生)
總人數上限：50人 |
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Ceiba 課程網頁 |
http://ceiba.ntu.edu.tw/1072Chem7027_ |
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課程簡介影片 |
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核心能力關聯 |
核心能力與課程規劃關聯圖 |
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課程大綱
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為確保您我的權利,請尊重智慧財產權及不得非法影印
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課程概述 |
本課程以化學系有機組碩士班與博士班學生為授課對象，學程半年，為4學分課程，總人數上限為40人。非有機組以及外系的學生建議應去修化學生物組的「高等化學生物學」，其實質內容亦為有機合成，偏重生物與藥學相關之課題。本課程使用之教材因內容極多，不可能所有內容一一含蓋，僅挑選其中最常用及重要的一些合成試劑及反應來討論，並加入一些我認為需要的內容。希望在本部份結束時，學生能對重要的官能基轉換及建立碳—碳鍵的方法有好的掌握。 |
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課程目標 |
本課程使用之教材因內容極多，不可能所有內容一一含蓋，僅挑選其中最常用及重要的一些合成試劑及反應來討論，並加入一些我認為需要的內容。希望在本部份結束時，學生能對重要 的官能基轉換及建立碳-碳鍵的方法有好的掌握。上課以投影片及寫黑板方式。 |
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課程要求 |
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預期每週課後學習時數 |
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Office Hours |
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指定閱讀 |
F.A. Carey and R.A. Sundberg "Advanced Organic Chemistry, Part B: Reactions and
Synthesis (5th Edition)." Plenum Press。 |
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參考書目 |
教課書：
F.A. Carey and R.A. Sundberg "Advanced Organic Chemistry, Part B: Reactions and
Synthesis (5th Edition)." Plenum Press。
其它參考書目：
題名/編著者/索書號
1 Advanced asymmetric synthesis / edited by G. R. Stephenson/QD262 A38z 1996
2 Asymmetric synthesis / edited by James D. Morrison/QD481 As99 v.2
3 Asymmetric synthesis / edited by James D. Morrison/QD481 As99 v.3
4 Basic organic stereochemistry / Ernest L. Eliel, Samuel H. Wilen, Michael P.
Doyle/QD481 E515 2001
5 Catalytic asymmetric synthesis / edited by Iwao Ojima/QD262 C357 2000
6 Classics in total synthesis II : more targets, strategies, methods / K.C.
Nicolaou and S.A. Snyder ; with a foreword by E.J. Corey/QD262 N52z 2003
7 Classics in total synthesis : targets, strategies, methods / K.C. Nicolaou and
E.J. Sorensen/QD262 N52 1996
8 Free radicals in organic chemistry / Jacques Fossey, Daniel Lefort, Janine
Sorba ; foreword by Alwyn Davies, Guy Ourisson ; translated by John Lomas/QD471
F71513 1995
9 The logic of chemical synthesis / E.J. Corey and Xue-Min Cheng/QD262 C577z
1989
10 Main group metals in organic synthesis / edited by Hisahi Yamamoto and
Koichiro Oshima/QD411.7.S94 M33z 2004 v.1
11 Main group metals in organic synthesis / edited by Hisahi Yamamoto and
Koichiro Oshima/QD411.7.S94 M33z 2004 v.2
12 March's advanced organic chemistry : reactions, mechanisms, and structure
/QD251.2 M37 2001
13 Metal carbenes in organic synthesis / Florencio Zaragoza Dorwald /QD305.H7
D67 1999
14 Modern organocopper chemistry / edited by Norbert Krause /QD412.C9 M64 2002
15 Modern oxidation methods / edited by Jan-Erling Backvall/ QD281.O9 M6z 2004
16 Organic syntheses based on name reactions / A. Hassner and C. Stumer /QD262
H324 2002
17 Organic synthesis : concepts and methods / Jurgen-Hinrich Fuhrhop, Guangtao
Li/QD262 F78z 2003
18 Organotin chemistry / Alwyn G. Davies/QD412.S7 D38 2004
19 Oxidations in organic chemistry / Miloš Hudlicky/QD281.O9 H83 1990
20 Reductions by the alumino- and borohydrides in organic synthesis / Jacqueline
Seyden-Penne/QD63.R4 S4913 1997
21 Silicon in organic synthesis / Ernest W. Colvin/QD 412 S6 C726
22 Synthetic organic photochemistry / edited by Axel G. Griesbeck and Jochen
Mattay/QD275 S95 2005
23 Transition metals for organic synthesis : building blocks and fine chemicals
/ edited by M. Beller and C. Bolm/QD262 T73z 2004 v.1
24 Transition metals for organic synthesis : building blocks and fine chemicals
/ edited by M. Beller and C. Bolm/QD262 T73z 2004 v.2
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評量方式
(僅供參考) |
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No. |
項目 |
百分比 |
說明 |
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1. |
期中考 |
30% |
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2. |
期末考 |
30% |
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3. |
口頭報告 |
25% |
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4. |
作業及出席率 |
15% |
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週次 |
日期 |
單元主題 |
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第1週 |
02/18, 02/22, 02/23 |
Chapter 3 Functional Group Interconversion by Substitution, Including Protection and Deprotection |
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第2週 |
02/25 |
Chapter 1 Alkylation of Enolates and Other Carbon Nucleophiles |
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第3週 |
03/04, 03/08 |
Chapter 1 Alkylation of Enolates and Other Carbon NucleophilesChapter 2 Reactions of Carbon Nucleophiles with Carbonyl Compounds |
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第4週 |
03/11, 03/15 |
Chapter 2 Reactions of Carbon Nucleophiles with Carbonyl Compounds |
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第5週 |
03/18, 03/22 |
Chapter 4 Electrophilic Additions to Carbon-Carbon Multiple Bonds |
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第6週 |
03/25, 03/29 |
Chapter 5 Reduction of Carbon-Carbon Multiple Bonds, Carbonyl Groups, and Other Functional Groups |
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第7週 |
04/01 |
Chapter 6 Concerted Cycloadditions, Unimolecular Rearrangements, and Thermal Eliminations |
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第8週 |
04/08, 04/12 |
Chapter 6 Concerted Cycloadditions, Unimolecular Rearrangements, and Thermal Eliminations |
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第9週 |
04/15, 04/19 |
Midterm |
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第10週 |
04/22, 04/26 |
Chapter 7 Organometallic Compounds of Group I and II Metals Chapter 8 Reactions Involving Transition Metals |
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第11週 |
04/29, 05/03 |
Chapter 8 Reactions Involving Transition Metals Chapter 9 Carbon-Carbon Bond-Forming Reactions of Compounds of Boron, Silicon, and Tin |
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第12週 |
05/06, 05/10 |
Chapter 9 Carbon-Carbon Bond-Forming Reactions of Compounds of Boron, Silicon, and Tin |
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第13週 |
05/13, 05/17 |
Chapter 10 Reactions Involving Carbocations, Carbenes, and Radicals as Reactive Intermediates |
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第14週 |
05/20, 05/24 |
Chapter 10 Reactions Involving Carbocations, Carbenes, and Radicals as Reactive Intermediates Chapter |
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第15週 |
05/27, 05/31 |
Chapter 10 Reactions Involving Carbocations, Carbenes, and Radicals as Reactive Intermediates Chapter 11 Aromatic Substitution Reactions |
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第16週 |
06/03, 06/07 |
Chapter 12 Oxidations |
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第17週 |
06/10, 06/14 |
Chapter 13 Multistep Syntheses |
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第18週 |
06/17 |
Final |
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